当我64岁时，你（肌钙蛋白、肌钙蛋白T和二氢吡啶受体）还会需要我吗？你（钙蛋白酶）还会裂解我吗？ - Suppr

Will you still need me (Ca , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?

作者信息

Pinto José Renato, Muller-Delp Judy, Chase P Bryant

机构信息

Department of Biomedical Sciences, The Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL, 32306-4300, USA.

Department of Biological Science, The Florida State University, 81 Chieftain Way, Tallahassee, FL, 32306-4370, USA.

出版信息

Aging Cell. 2017 Apr;16(2):202-204. doi: 10.1111/acel.12560. Epub 2016 Dec 23.

DOI:10.1111/acel.12560

PMID:28008709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5334566/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d6e/5334566/d47b8ad00fd2/ACEL-16-202-g001.jpg

相似文献

Will you still need me (Ca , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?当我64岁时，你（肌钙蛋白、肌钙蛋白T和二氢吡啶受体）还会需要我吗？你（钙蛋白酶）还会裂解我吗？

Aging Cell. 2017 Apr;16(2):202-204. doi: 10.1111/acel.12560. Epub 2016 Dec 23.

Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice.钙蛋白酶抑制可挽救肌钙蛋白T3片段化，增加Cav1.1，并增强老龄久坐小鼠的骨骼肌力量。

Aging Cell. 2016 Jun;15(3):488-98. doi: 10.1111/acel.12453. Epub 2016 Feb 19.

The SH3 and cysteine-rich domain 3 (Stac3) gene is important to growth, fiber composition, and calcium release from the sarcoplasmic reticulum in postnatal skeletal muscle.SH3和富含半胱氨酸结构域3（Stac3）基因对出生后骨骼肌的生长、纤维组成以及肌浆网钙释放至关重要。

Skelet Muscle. 2016 Apr 11;6:17. doi: 10.1186/s13395-016-0088-4. eCollection 2016.

Proteomic study of calpain interacting proteins during skeletal muscle aging.骨骼肌衰老过程中钙蛋白酶相互作用蛋白的蛋白质组学研究。

Biochimie. 2010 Dec;92(12):1923-33. doi: 10.1016/j.biochi.2010.09.003. Epub 2010 Sep 17.

Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.小鼠骨骼肌中缺乏二氢吡啶受体（DHPR）和兰尼碱受体（RyR）时肌浆网表面连接的形态学和分子组成

Biophys J. 2002 Jun;82(6):3144-9. doi: 10.1016/S0006-3495(02)75656-7.

Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle.骨骼肌中钙通道基因转录的年龄依赖性胰岛素样生长因子-1调节

Mech Ageing Dev. 2001 Apr 15;122(4):373-84. doi: 10.1016/s0047-6374(00)00236-0.

Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle.胰岛素样生长因子-1对衰老骨骼肌兴奋收缩偶联的调节作用

J Nutr Health Aging. 2000;4(3):162-4.

Aging Cell. 2012 Dec;11(6):1036-45. doi: 10.1111/acel.12003. Epub 2012 Oct 4.

T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.T 管重塑和兰尼碱受体构象调节钠钙交换。

Adv Exp Med Biol. 2013;961:375-83. doi: 10.1007/978-1-4614-4756-6_32.

Arg(615)Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop.猪骨骼肌兰尼碱受体中的精氨酸（615）向半胱氨酸的替换增强了由一段骨骼肌二氢吡啶受体II-III环所引起的单通道激活。

Biophys J. 2001 Apr;80(4):1769-82. doi: 10.1016/S0006-3495(01)76147-4.

引用本文的文献

The Effect of Acute and Chronic Thermotherapy on Type 2 Diabetic Skeletal Muscle Gene Expression and Inflammatory Markers.急性和慢性热疗对2型糖尿病骨骼肌基因表达及炎症标志物的影响

Biomedicines. 2021 Sep 21;9(9):1276. doi: 10.3390/biomedicines9091276.

Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous Variants.与复合杂合变异体新组合相关的家族性扩张型心肌病

Front Physiol. 2020 Jan 22;10:1612. doi: 10.3389/fphys.2019.01612. eCollection 2019.

Cardiomyocyte nuclearity and ploidy: when is double trouble?心肌细胞核型和倍性：何时会出现双重麻烦？

J Muscle Res Cell Motil. 2020 Dec;41(4):329-340. doi: 10.1007/s10974-019-09545-7. Epub 2019 Jul 17.

The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy.梭内肌纤维中慢骨骼肌肌钙蛋白 T 同工型的缺失解释了阿什肯纳兹型先天性肌营养不良的病理生理学。

J Physiol. 2019 Aug;597(15):3999-4012. doi: 10.1113/JP278119. Epub 2019 Jul 3.

Modeling Renal Disease "On the Fly".在飞行中模拟肾脏疾病。

Biomed Res Int. 2018 May 31;2018:5697436. doi: 10.1155/2018/5697436. eCollection 2018.

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction.肌钙蛋白的别样视角：超越调节横纹肌收缩的新作用

Oncotarget. 2017 Dec 4;9(1):1461-1482. doi: 10.18632/oncotarget.22879. eCollection 2018 Jan 2.

The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents.去卵巢大鼠中肥胖、骨质疏松症和肌肉减少症的共现：一项在啮齿动物中建立骨质疏松性肥胖模型的研究。

J Aging Res. 2017;2017:1454103. doi: 10.1155/2017/1454103. Epub 2017 Jun 1.

本文引用的文献

Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.Stac3在骨骼肌型兴奋-收缩偶联中起直接作用，该作用会因一种导致肌病的突变而受到破坏。

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10986-91. doi: 10.1073/pnas.1612441113. Epub 2016 Sep 12.

Aging Cell. 2016 Jun;15(3):488-98. doi: 10.1111/acel.12453. Epub 2016 Feb 19.

Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease.细胞内兰尼碱受体1型钙释放通道在骨骼肌功能和疾病中的关键作用

Front Physiol. 2016 Jan 12;6:420. doi: 10.3389/fphys.2015.00420. eCollection 2015.

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.磷酸二酯酶2A和3A的表观遗传调控是扩张型心肌病iPSC模型中β-肾上腺素能信号受损的基础。

Cell Stem Cell. 2015 Jul 2;17(1):89-100. doi: 10.1016/j.stem.2015.04.020. Epub 2015 Jun 18.

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.钙离子渗透和/或与 Cav1.1 结合可精细调节骨骼肌钙离子信号，以维持肌肉功能。

Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015.

Regenerating skeletal muscle in the face of aging and disease.在衰老和疾病情况下再生骨骼肌。

Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S88-96. doi: 10.1097/PHM.0000000000000118.

A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.斑马鱼胚胎培养系统定义了跨物种促进脊椎动物肌发生的因素。

Cell. 2013 Nov 7;155(4):909-921. doi: 10.1016/j.cell.2013.10.023.

Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?横纹肌中的核原肌球蛋白和肌钙蛋白：新位置的新作用？

J Muscle Res Cell Motil. 2013 Aug;34(3-4):275-84. doi: 10.1007/s10974-013-9356-7. Epub 2013 Aug 2.

The hallmarks of aging.衰老的特征。

Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.

Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis.非肌丝相关肌钙蛋白 T3 的核定位序列和核仁定位序列及亮氨酸拉链结构域介导肌细胞凋亡。

Cytoskeleton (Hoboken). 2013 Mar;70(3):134-47. doi: 10.1002/cm.21095. Epub 2013 Feb 1.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Will you still need me (Ca , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献