Ahmad Khurshid, Khan Mohd Kalim A, Baig Mohammad Hassan, Imran Mohd, Gupta Girish Kumar
National Bureau of Agriculturally Important Microorganisms, Kushmaur, Mau Nath Bhanjan-275103, Uttar Pradesh, India.
Department of Bioengineering, Integral University, Lucknow-226026, India.
Anticancer Agents Med Chem. 2018;18(1):46-56. doi: 10.2174/1871520616666161221112042.
Cancer has gradually become one of the leading causes of death worldwide. The incidence of cancer among the population has increased alarmingly over the last two decades, primarily due to an increasing population of immune-compromised patients and the continuing rise in anti-cancer drug resistance. Azole found privileged structure in medicinal chemistry and pharmaceutical industry and also found to be showing antioxidant; antimicrobial, anthelmintic, anticancer, antiviral, anti-parasitic, anti-inflammatory, anti-HIV, and antihypertensive activities.
In this review, we highlight some areas of current interest in context to azoles and their derivatives as potential chemotherapeutic agents and inhibitors.
A comprehensive literature search was performed for writing this review. An updated view on different derivatives of azoles and use in cancer management has been discussed.
Here we have discussed the present scenario of azoles and their derivatives as potential chemotherapeutic agents and inhibitors. Along with, the future perspectives of azoles in cancer prevention and treatment are also discussed.
The information provided in this review might be useful to researchers in designing of novel and potent multifunctional azole analogues for the treatment of cancer and other multifactorial diseases.
癌症已逐渐成为全球主要死因之一。在过去二十年中，人群中的癌症发病率急剧上升，主要原因是免疫功能低下患者数量增加以及抗癌药物耐药性持续上升。唑类在药物化学和制药行业中具有特殊结构，并且还具有抗氧化、抗菌、驱虫、抗癌、抗病毒、抗寄生虫、抗炎、抗艾滋病毒和抗高血压活性。
在本综述中，我们重点介绍了唑类及其衍生物作为潜在化疗药物和抑制剂目前的一些研究热点领域。
为撰写本综述进行了全面的文献检索。讨论了唑类不同衍生物及其在癌症治疗中的应用的最新观点。
在此我们讨论了唑类及其衍生物作为潜在化疗药物和抑制剂的现状。同时，还讨论了唑类在癌症预防和治疗方面的未来前景。
本综述提供的信息可能有助于研究人员设计新型高效的多功能唑类类似物，用于治疗癌症和其他多因素疾病。
