青少年中客观测量的身体活动与脑源性神经营养因子的横断面关联。
Cross-sectional associations of objectively measured physical activity with brain-derived neurotrophic factor in adolescents.
作者信息
Huang Tao, Gejl Anne Kær, Tarp Jakob, Andersen Lars Bo, Peijs Lone, Bugge Anna
机构信息
Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China.
Centre of Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
出版信息
Physiol Behav. 2017 Mar 15;171:87-91. doi: 10.1016/j.physbeh.2016.12.026. Epub 2016 Dec 24.
OBJECTIVE
The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents.
METHODS
Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015 follow-up of the Childhood Health Activity and Motor Performance School Study Denmark (the CHAMPS-study DK). Physical activity was objectively measured by accelerometry monitors. Serum BDNF levels were analyzed using the Enzyme-linked immunosorbent assay (ELISA). Anthropometrics and pubertal status were measured using standardized procedures.
RESULTS
With adjustment for age, pubertal status and body mass index, mean physical activity (counts per minute) was negatively associated with serum BDNF in boys (P=0.013). Similarly, moderate-to-vigorous physical activity (MVPA) was negatively associated with serum BDNF in boys (P=0.035). In girls, mean physical activity and MVPA were not associated with serum BDNF. Without adjustment for wear time, sedentary time was not associated with serum BDNF in either sex.
CONCLUSION
These findings indicate that higher physical activity is associated with lower serum BDNF in boys, but not in girls.
目的
本研究旨在探讨青少年客观测量的身体活动与血清脑源性神经营养因子（BDNF）之间的关联。
方法
采用丹麦儿童健康活动与运动表现学校研究（CHAMPS研究DK）2015年随访中415名青少年的数据进行横断面分析。通过加速度计监测仪客观测量身体活动。采用酶联免疫吸附测定（ELISA）分析血清BDNF水平。使用标准化程序测量人体测量学指标和青春期状态。
结果
在调整年龄、青春期状态和体重指数后，男孩的平均身体活动（每分钟计数）与血清BDNF呈负相关（P = 0.013）。同样，男孩的中度至剧烈身体活动（MVPA）与血清BDNF呈负相关（P = 0.035）。在女孩中，平均身体活动和MVPA与血清BDNF无关联。在未调整佩戴时间的情况下，久坐时间与两性的血清BDNF均无关联。
结论
这些发现表明，较高的身体活动与男孩较低的血清BDNF相关，但与女孩无关。
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