食品添加剂在复发性阿弗他口炎中起作用吗？一项斑贴试验的前瞻性研究。
Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing.
作者信息
Gülseren Duygu, Hapa Asli, Ersoy-Evans Sibel, Elçin Gonca, Karaduman Ayşen
机构信息
Hacettepe University, School of Medicine, Department of Dermatology, Ankara, Turkey.
University of Virginia Medical Center, Division of Dermatopathology, Charlottesville, VA, USA.
出版信息
Int J Dermatol. 2017 Mar;56(3):302-306. doi: 10.1111/ijd.13515. Epub 2016 Dec 30.
BACKGROUND
Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS.
METHODS
This prospective study included 24 patients with RAS and 22 healthy controls. All the participants underwent patch testing for 23 food additives.
RESULTS
In total, 21 (87.5%) RAS patients and 3 (13.6%) controls had positive patch test reactions to ≥1 allergens; the difference in the patch test positivity rate between groups was significant (P < 0.05). The most common allergen that elicited positive patch test results in the patient group was cochineal red (n = 15 [62.5%]), followed by azorubine (n = 11 [45.8%]) and amaranth (n = 6 [25%]).
CONCLUSIONS
The present findings show that food additives might play a role in the etiology of RAS and that patch testing could be a method for determining the etiology of RAS.
背景
复发性阿弗他口炎（RAS）是一种常见的口腔黏膜疾病，病因不明。本研究旨在确定食品添加剂是否在RAS的病因中起作用，以及斑贴试验是否可用于检测哪些过敏原导致RAS。
方法
这项前瞻性研究纳入了24例RAS患者和22名健康对照者。所有参与者均接受了23种食品添加剂的斑贴试验。
结果
总体而言，21例（87.5%）RAS患者和3例（13.6%）对照者对≥1种过敏原的斑贴试验反应呈阳性；两组间斑贴试验阳性率差异有统计学意义（P<0.05）。在患者组中引起斑贴试验阳性结果的最常见过敏原是胭脂红（n=15[62.5%]），其次是偶氮玉红（n=11[45.8%]）和苋菜红（n=6[25%]）。
结论
目前的研究结果表明，食品添加剂可能在RAS的病因中起作用，斑贴试验可能是确定RAS病因的一种方法。
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