血管生成素与神经性厌食症女孩的骨骼状态选定指标
Vaspin and selected indices of bone status in girls with anorexia nervosa.
作者信息
Ostrowska Zofia, Ziora Katarzyna, Oświęcimska Joanna, Świętochowska Elżbieta, Marek Bogdan, Kajdaniuk Dariusz, Strzelczyk Joanna, Gołąbek Karolina, Morawiecka-Pietrzak Małgorzata, Wołkowska-Pokrywa Kinga, Kos-Kudła Beata
机构信息
Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
出版信息
Endokrynol Pol. 2016;67(6):599-606. doi: 10.5603/EP.2016.0070.
INTRODUCTION
In vitro studies indicate that vaspin may act as a regulator of bone metabolism. The aim of the study was to evaluate the relationship between vaspin and bone metabolism in girls with anorexia nervosa (AN), as well as the potential involvement of OPG and RANKL in this relationship.
MATERIAL AND METHODS
Serum vaspin, OC, CTx, OPG, and sRANKL were determined by ELISA in 50 girls with AN and in 30 healthy controls aged 13 to 17 years.
RESULTS
Girls with AN exhibited significant reduction in body weight, BMI, and Cole index as well as a significant increase in serum level of vaspin compared to healthy participants. These changes were associated with a significant decrease in serum OC and CTx levels and a significant increase in OPG and sRANKL, while the OPG/sRANKL ratio was significantly decreased. BMI and Cole index correlated negatively and significantly with CTx levels in the control group (C), girls with AN, and all study participants (C+AN). Girls with AN showed a significant negative correlation between BMI, the Cole index, and OPG levels. The combination group (C+AN) showed a significant positive correlation between BMI, Cole index, and the OPG/sRANKL ratio. In this group of girls vaspin levels correlated positively and significantly with sRANKL and negatively with body weight, BMI, Cole index, and OPG/sRANKL ratio. Girls with AN showed a significant negative correlation between vaspin levels and the OPG/sRANKL ratio.
CONCLUSIONS
Undernourishment and associated deficit of adipose tissue may result in inadequate vaspin production and bone metabolism disorders in girls with AN. Vaspin acts as a coordinator of the dynamic balance between bone formation and resorption processes; its action is affected by the cytokines of the RANKL/RANK/OPG system. Changes in the relationships between vaspin, bone markers, OPG, and RANKL might contribute to the development of osteoporosis in girls with AN. (Endokrynol Pol 2016; 67 (6): 599-606).
引言
体外研究表明，内脏脂肪素可能是骨代谢的调节因子。本研究旨在评估神经性厌食症（AN）女孩体内内脏脂肪素与骨代谢之间的关系，以及骨保护素（OPG）和核因子κB受体活化因子配体（RANKL）在这种关系中的潜在作用。
材料与方法
采用酶联免疫吸附测定法（ELISA）测定50例AN女孩和30例年龄在13至17岁的健康对照者血清中的内脏脂肪素、骨钙素（OC）、I型胶原交联C末端肽（CTx）、OPG和可溶性RANKL（sRANKL）。
结果
与健康参与者相比，AN女孩的体重、体重指数（BMI）和科尔指数显著降低，血清内脏脂肪素水平显著升高。这些变化与血清OC和CTx水平显著降低以及OPG和sRANKL显著升高有关，而OPG/sRANKL比值显著降低。在对照组（C）、AN女孩以及所有研究参与者（C+AN）中，BMI和科尔指数与CTx水平呈显著负相关。AN女孩的BMI、科尔指数与OPG水平呈显著负相关。联合组（C+AN）的BMI、科尔指数与OPG/sRANKL比值呈显著正相关。在这组女孩中，内脏脂肪素水平与sRANKL呈显著正相关，与体重、BMI、科尔指数和OPG/sRANKL比值呈负相关。AN女孩的内脏脂肪素水平与OPG/sRANKL比值呈显著负相关。
结论
营养不良及相关的脂肪组织缺乏可能导致AN女孩内脏脂肪素产生不足和骨代谢紊乱。内脏脂肪素是骨形成和骨吸收过程动态平衡的协调者；其作用受RANKL/RANK/OPG系统细胞因子的影响。内脏脂肪素、骨标志物、OPG和RANKL之间关系的变化可能促使AN女孩发生骨质疏松。（《波兰内分泌学》2016年；67（6）：599 - 606）
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