银催化2-三氟甲基-1,3-烯炔与伯胺的串联氢胺化和环化反应：通往4-三氟甲基-3-吡咯啉的模块化合成方法
Silver-catalysed tandem hydroamination and cyclization of 2-trifluoromethyl-1,3-enynes with primary amines: modular entry to 4-trifluoromethyl-3-pyrrolines.
作者信息
Zhou Xiaofan, Huang Chaoqian, Zeng Yu, Xiong Jiarui, Xiao Yuanjing, Zhang Junliang
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R. China.
出版信息
Chem Commun (Camb). 2017 Jan 17;53(6):1084-1087. doi: 10.1039/c6cc09595j.
A highly efficient tandem hydroamination and cyclization reaction of 2-trifluoromethyl-1,3-enynes with primary amines leading to 4-trifluoromethyl-3-pyrrolines was developed by using AgNO as a catalyst under mild reaction conditions. This new method is compatible with alkyl, aryl, and allyl primary amines, representing an atom-economical protocol for the construction of 4-trifluoromethyl-3-pyrrolines for the first time.
在温和的反应条件下，以硝酸银为催化剂，开发了一种2-三氟甲基-1,3-烯炔与伯胺的高效串联氢胺化和环化反应，可生成4-三氟甲基-3-吡咯啉。这种新方法与烷基、芳基和烯丙基伯胺兼容，首次代表了一种构建4-三氟甲基-3-吡咯啉的原子经济方案。
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