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[唐氏综合征与新生儿狼疮继发的心脏传导阻滞]

[Down syndrome and heart block secondary to neonatal lupus].

作者信息

Illana-Bravo Carla Lucila, Méndez-Martínez Socorro, Juan-Martínez María Enriqueta

机构信息

Departamento de Cardiología Pediátrica, Hospital General Regional 36, Instituto Mexicano del Seguro Social, Puebla, Puebla, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2017 Jan-Feb;55(1):128-132.

Abstract

In Down syndrome, so far, has not been reported it's association with congenital heart block, this entity is rare and occurred in only 1% of mothers who have systemic lupus erythematosus, the presence of anti-Ro antibodies cross the placenta presenting neonatal lupus with skin lesions and congenital heart block, bradycardia, which is why we describe the following case. This is a new male end product of asymptomatic young mother, but serological birth with stigmata of Down syndrome, birth presents congenital bradycardia rare manifestation abnormalities, but common in children of mothers with lupus are initiated study protocol, realizing you including laboratory tests and immunological studies cabinet as electrocardiogram and echocardiogram, which gave tone to take the mother immunological studies, being positive antiRo. We concluded that the risk of heart block in a patient with Down syndrome is the same as for the general population.

摘要

在唐氏综合征中,迄今为止,尚未报道其与先天性心脏传导阻滞有关,这种情况很罕见,仅发生在患有系统性红斑狼疮的母亲中的1%,抗Ro抗体的存在会穿过胎盘,导致新生儿狼疮伴有皮肤病变和先天性心脏传导阻滞、心动过缓,这就是我们描述以下病例的原因。这是一名无症状年轻母亲的新出生男婴,但出生时血清学检查有唐氏综合征的体征,出生时出现先天性心动过缓这种罕见的表现异常,但在狼疮母亲的孩子中很常见,于是启动了研究方案,包括进行实验室检查和免疫研究,如心电图和超声心动图,这促使对母亲进行免疫研究,结果抗Ro呈阳性。我们得出结论,唐氏综合征患者发生心脏传导阻滞的风险与普通人群相同。

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