从夏威夷血红六鳃海蛞蝓卵块中分离出的乌拉普阿内酯C - E。
Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass.
作者信息
Parrish Stephen M, Yoshida Wesley, Yang Baojun, Williams Philip G
机构信息
Department of Chemistry, University of Hawaii at Manoa , Honolulu, Hawaii 96822, United States.
University of Hawaii Cancer Center , 701 Ilalo Street, Honolulu, Hawaii 96813, United States.
出版信息
J Nat Prod. 2017 Mar 24;80(3):726-730. doi: 10.1021/acs.jnatprod.6b00896. Epub 2017 Jan 18.
Abstract
Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.
摘要
从裸鳃亚目动物血红六鳃海蛞蝓的卵块中分离出了三种新的乌拉普阿利德（3 - 5）。通过对物理和光谱数据的分析，并与乌拉普阿利德A（1）和B（2）进行比较，推断出了3 - 5的结构。乌拉普阿利德C对选定的美国国立癌症研究所（NCI）细胞系（768 - 0、DU - 145、MDA - MB - 231和A549）表现出亚微摩尔级的细胞毒性，对MDA - MB - 231细胞的活性最强（IC 0.58 μM）。乌拉普阿利德A（1）和B（2）的效力比3强2至4倍。
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