用于卵巢癌检测的光学相干断层扫描（OCT）与宽视野成像输卵管镜组合装置的设计与特性分析
Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection.
作者信息
Keenan Molly, Tate Tyler H, Kieu Khanh, Black John F, Utzinger Urs, Barton Jennifer K
机构信息
University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA.
University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
出版信息
Biomed Opt Express. 2016 Dec 8;8(1):124-136. doi: 10.1364/BOE.8.000124. eCollection 2017 Jan 1.
Abstract
Early detection of ovarian cancer is only achieved in around 20% of women due to lack of effective screening. We propose a method for surveillance of high risk women based on a microendoscope introduced transvaginally to image the fallopian tubes and ovaries. This requires extreme miniaturization of the optics and catheter sheath. We describe the design of a falloposcope that combines optical coherence tomography (OCT) and wide field imaging into a sub-1 mm diameter package. We characterize the systems and show that they provide contrast on samples of ovary and fallopian tube. In addition, we show the mechanical performance of the endoscope in an anatomically correct model of the female reproductive tract.
摘要
由于缺乏有效的筛查手段，只有约20%的女性能够实现卵巢癌的早期检测。我们提出了一种基于经阴道插入的微型内窥镜对高危女性进行监测的方法，以对输卵管和卵巢进行成像。这需要光学器件和导管鞘极度小型化。我们描述了一种输卵管镜的设计，该设计将光学相干断层扫描（OCT）和宽视野成像集成到一个直径小于1毫米的组件中。我们对该系统进行了表征，并表明它们能在卵巢和输卵管样本上提供对比度。此外，我们展示了该内窥镜在女性生殖道解剖学正确模型中的机械性能。
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