Wang Z, Wang E H, Liu D G
Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.
Zhonghua Zhong Liu Za Zhi. 2017 Jan 23;39(1):1-6. doi: 10.3760/cma.j.issn.0253-3766.2017.01.001.
The cell origin of primary pulmonary mucinous epithelial tumors includes goblet cells, tracheobronchial mucous glands, the mucous cell metaplasia of ciliated and Clara cells, etc.There are benign, low-grade malignant potential and malignant tumors in this category. The benign tumors encompass mucous gland adenoma and mucinous cystadenoma. Ciliated muconodular papillary tumors are thought to be of low grade malignant potential or uncertain malignant potential neoplasm, while colloid adenocarcinoma and mucinous adenocarcinoma are malignant tumors. Most of primary pulmonary mucinous epithelial tumors are rare even extremely rare lesions. Similar morphological changes exist in the different tumors. Differential diagnosis for these entities may be challenging in pathological diagnosis on biopsies, even surgical sections. The clinicopathologic characteristics should be carefully analyzed to ensure accurate pathologic diagnosis for primary pulmonary mucinous epithelial tumors.
原发性肺黏液上皮性肿瘤的细胞起源包括杯状细胞、气管支气管黏液腺、纤毛细胞和克拉拉细胞的黏液细胞化生等。该类别中有良性、低度恶性潜能和恶性肿瘤。良性肿瘤包括黏液性腺瘤和黏液性囊腺瘤。纤毛黏液结节性乳头状肿瘤被认为是低度恶性潜能或恶性潜能不确定的肿瘤,而胶样腺癌和黏液腺癌则是恶性肿瘤。大多数原发性肺黏液上皮性肿瘤是罕见甚至极其罕见的病变。不同肿瘤中存在相似的形态学改变。在活检甚至手术切片的病理诊断中,对这些实体进行鉴别诊断可能具有挑战性。应仔细分析临床病理特征,以确保对原发性肺黏液上皮性肿瘤做出准确的病理诊断。