Song Peige, Yu Jinyue, Chang Xinlei, Wang Manli, An Lin
Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing 100191, China.
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Nutrients. 2017 Jan 18;9(1):79. doi: 10.3390/nu9010079.
Metabolic syndrome (MetS) is generally defined as a cluster of metabolically related cardiovascular risk factors which are often associated with the condition of insulin resistance, elevated blood pressure, and abdominal obesity. During the past decades, MetS has become a major public health issue worldwide in both adults and children. In this study, data from the China Health and Nutrition Surveys (CHNS) was used to assess the prevalence of MetS based on both the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) guidelines and the International Diabetes Federation (IDF) criteria, and to evaluate its possible correlates. A total of 831 children aged 7-18 years were included in this study, and 28 children were classified as having MetS as defined by the modified NCEP-ATPIII definition, which yielded an overall prevalence of 3.37%. Elevated blood pressure was the most frequent MetS component. The results of logistic regression models revealed that increased body mass index (BMI), hyperuricemia, and insulin resistance (IR) were all associated with the presence of MetS. To conclude, our study revealed the prevalence of MetS in Chinese children at the national level. Further large-scale studies are still needed to identify better MetS criteria in the general paediatric population in China.
代谢综合征(MetS)通常被定义为一组与代谢相关的心血管危险因素,这些因素常与胰岛素抵抗、血压升高和腹部肥胖状况相关。在过去几十年中,代谢综合征已成为全球范围内成人和儿童的一个主要公共卫生问题。在本研究中,来自中国健康与营养调查(CHNS)的数据被用于根据美国国家胆固醇教育计划成人治疗小组第三次报告(NCEP-ATPIII)指南和国际糖尿病联盟(IDF)标准评估代谢综合征的患病率,并评估其可能的相关因素。本研究共纳入831名7至18岁的儿童,其中28名儿童被归类为患有根据修改后的NCEP-ATPIII定义确定的代谢综合征,总体患病率为3.37%。血压升高是最常见的代谢综合征组成部分。逻辑回归模型的结果显示,体重指数(BMI)升高、高尿酸血症和胰岛素抵抗(IR)均与代谢综合征的存在相关。总之,我们的研究揭示了中国儿童在全国范围内代谢综合征的患病率。仍需要进一步的大规模研究来确定中国普通儿科人群中更好的代谢综合征标准。