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利用癌细胞膜进行仿生工程设计,构建具有细胞器样功能的分隔纳米反应器。

Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions.

机构信息

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI, 00014, Helsinki, Finland.

Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.

出版信息

Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201605375. Epub 2017 Jan 23.

Abstract

A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles.

摘要

本文提出了一种基于癌细胞膜材料与多孔硅纳米粒子相结合的新型仿生纳米反应器设计。这种细胞纳米反应器具有细胞膜包围的生物隔室,可与细胞轻易集成,并在氧化应激下补充细胞功能。该研究表明,纳米反应器对改善细胞功能具有重要影响,有望成为人工细胞器。

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