系统性红斑狼疮患者静脉注射脉冲式甲泼尼龙治疗后出现窦性心动过缓。

Sinus bradycardia after intravenous pulse methylprednisolone therapy in patients with systemic lupus erythematosus.

作者信息

Ohshima Miho, Kawahata Kimito, Kanda Hiroko, Yamamoto Kazuhiko

机构信息

a Department of Allergy and Rheumatology , University of Tokyo , Tokyo , Japan.

b Department of Rheumatic Diseases , Tama-Hokubu Medical Center, Health and Medical Treatment Corporation , Tokyo , Japan.

出版信息

Mod Rheumatol. 2019 Jul;29(4):700-703. doi: 10.1080/14397595.2016.1276246. Epub 2017 Feb 1.

DOI:10.1080/14397595.2016.1276246

PMID:28121197

Abstract

Sinus bradycardia is reported as an adverse effect of high-dose glucocorticoid therapy. We report three cases of systemic lupus erythematosus, wherein intravenous pulse methylprednisolone was administered. The patients' average baseline heart rate was 72 beats/min, which decreased 30% from baseline at 61 h after beginning the therapy. The average minimum heart rate was 38 beats/min, and this rate continued for 169 h on average. No other causes for bradycardia were found, suggesting that the administration of glucocorticoid pulse therapy resulted in decreased heart rate.

摘要

窦性心动过缓被报道为大剂量糖皮质激素治疗的一种不良反应。我们报告了3例系统性红斑狼疮患者，他们接受了静脉注射甲基强的松龙脉冲治疗。患者的平均基线心率为72次/分钟，在开始治疗后61小时，心率较基线下降了30%。平均最低心率为38次/分钟，且该心率平均持续了169小时。未发现其他导致心动过缓的原因，提示糖皮质激素脉冲治疗导致了心率下降。