血清总抗氧化能力水平低，入院时存在且出院时不存在昼夜变化可作为急性偏执型精神分裂症复发的标志物。

Low levels of serum total antioxidant capacity and presence at admission and absence at discharge of a day/night change as a marker of acute paranoid schizophrenia relapse.

机构信息

Departamento de Medicina Interna, Dermatología y Psiquiatría, Facultad de Medicina, Universidad de La Laguna (ULL), 38071. La Laguna, Santa Cruz de Tenerife, Islas Canarias, Spain; Consultoria Psiquiátrica, Santa Cruz de Tenerife, Islas Canarias, Spain.

Servicio de Psiquiatría, Hospital Universitario de Canarias, Ofra. Santa Cruz de Tenerife, Spain.

出版信息

Psychiatry Res. 2017 Mar;249:200-205. doi: 10.1016/j.psychres.2017.01.043. Epub 2017 Jan 19.

DOI:10.1016/j.psychres.2017.01.043

PMID:28126575

Abstract

BACKGROUND

An oxidant-antioxidant system dysregulation has been described as a schizophrenia pathophysiological base. The total antioxidant capacity (TAC) is one measure of the antioxidant capacity of a system. Day/night concentration changes is a biological characteristic of hormones such as melatonin or cortisol. There is no information about TAC day/night changes in schizophrenia.

AIMS

Studying the existence of a day/night TAC change in schizophrenia.

METHOD

Forty-three DSM-IV paranoid schizophrenia inpatients participated in the study. Thirty healthy subjects matched by age and gender acted as control group. Blood was sampled at 12:00 and 00:00h the day after admission and the day before discharge. Serum TAC was measured by the ABTS radical cation technique and expressed in Trolox mmol/L.

RESULTS

Patients had significantly lower TAC levels at admission and discharge (12:00 and 00:00) than controls. At admission patients had a TAC day/night change, with higher day-time than night-time levels (0.66±0.14 vs 0.60±0.15) as well as healthy subjects (0.83±0.07 vs 0.77±0.11). At discharge patients had a similar TAC level at 12:00 and 00:00 (0.64±0.15 vs 0.63±0.14).

CONCLUSION

Schizophrenic patients present a deficit of the antioxidant system. The initial presence and the later absence of a day/night change deserves future studies.

摘要

背景

氧化还原系统失调已被描述为精神分裂症的病理生理基础。总抗氧化能力 (TAC) 是衡量系统抗氧化能力的一个指标。昼夜浓度变化是褪黑素或皮质醇等激素的生物学特征。目前尚无关于精神分裂症 TAC 昼夜变化的信息。

目的

研究精神分裂症是否存在 TAC 的昼夜变化。

方法

43 名 DSM-IV 偏执型精神分裂症住院患者参与了这项研究。30 名年龄和性别匹配的健康受试者作为对照组。入院后第二天和出院前一天的 12:00 和 00:00 采集血液样本。采用 ABTS 自由基阳离子技术测定血清 TAC，以 Trolox mmol/L 表示。

结果

与对照组相比，患者在入院和出院时（12:00 和 00:00）的 TAC 水平显著降低。入院时，患者的 TAC 存在昼夜变化，日间水平高于夜间水平（0.66±0.14 比 0.60±0.15），与健康受试者相似（0.83±0.07 比 0.77±0.11）。出院时，患者在 12:00 和 00:00 的 TAC 水平相似（0.64±0.15 比 0.63±0.14）。