Ding Shengguang, Huang Haitao, Xu Yiming, Zhu Hao, Zhong Chongjun
Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.
Biomed Res Int. 2017;2017:4962426. doi: 10.1155/2017/4962426. Epub 2017 Jan 3.
MicroRNAs (miRNAs and miRs) are endogenous 19-22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart. Here we reviewed the recent studies about the roles of miR-222 in cardiovascular diseases. MiR-222 may be a potential cardiovascular biomarker and a new therapeutic target in cardiovascular diseases.
微小RNA（miRNA，也称miR）是内源性的19 - 22个核苷酸的小型非编码RNA，具有高度保守性和组织特异性表达。它们可通过减少转录或转录后诱导mRNA降解来负向调节靶基因表达。越来越多的证据表明，失调的miRNA在心血管疾病的发生中起重要作用。此外，循环miRNA可作为心血管疾病的生物标志物。据报道，miR - 222在心脏的多种生理和病理过程中发挥重要作用。在此，我们综述了关于miR - 222在心血管疾病中作用的最新研究。miR - 222可能是一种潜在的心血管生物标志物以及心血管疾病的新治疗靶点。
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