Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis.
作者信息
Ong Sally S, Walter Scott D, Chen Xi, Vora Gargi K, Daluvoy Melissa, Proia Alan D, Mruthyunjaya Prithvi
机构信息
Departments of *Ophthalmology; †Pathology; and ‡Radiation Oncology, Duke University Medical Center, Durham, NC; and §Department of Ophthalmology, Stanford University Medical Center, Palo Alto, CA.
出版信息
Cornea. 2017 Apr;36(4):502-505. doi: 10.1097/ICO.0000000000001144.
PURPOSE
Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC).
METHODS
Case report.
RESULTS
A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids.
CONCLUSIONS
Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.
Zotero 插件