利用斑马鱼进行化学筛选以发现新的生物学特性和治疗方法。
Chemical screening in zebrafish for novel biological and therapeutic discovery.
作者信息
Wiley D S, Redfield S E, Zon L I
机构信息
Stem Cell Program and Division of Hematology and Oncology, Childrens' Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, United States.
出版信息
Methods Cell Biol. 2017;138:651-679. doi: 10.1016/bs.mcb.2016.10.004. Epub 2016 Dec 29.
Abstract
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
摘要
斑马鱼化学筛选可对生物过程的小分子调节进行体内评估。利用这种方法可以研究化合物毒性、代谢引起的化学变化、药代动力学和药效学特性以及细胞微环境的调节。此外，斑马鱼筛选操作简单且成本效益高。斑马鱼为通过化学筛选发现新型疗法提供了一个宝贵的平台。
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