Kojima Tadahiro, Akai Toshiya, Nakamura Koichi, Higashi Yukihiro, Shoji Tsuyoshi, Yamazaki Masanori, Taniguchi Masami, Nishiyama Raisuke, Maruo Hirotoshi
Dept. of Surgery, Shizuoka City Shimizu Hospital.
Gan To Kagaku Ryoho. 2016 Nov;43(12):2231-2233.
We describe a 67-year-old man with long-term CR by S-1 chemotherapy for gastric cancer with para-aortic lymph node metastases after reduction surgery. The patient presented at our hospital with epigastric pain. He was diagnosed with gastric cancer with para-aortic lymph node metastases. We performed gastrectomy and D1 lymphadenectomy without any resection of the para-aortic lymph node metastases. We treated the patient with oral S-1 chemotherapy. The initial treatment schedule was 100mg/body/day, twice daily for 4weeks with 2weeks of rest. Grade 1 neutropenia developed at the end of the second course of treatment. The regimen was changed to 2 weeks of administration, with 1 week of rest. The para-aortic lymph node metastases immediately responded to the chemotherapy. Abdominal CT showed almost complete regression of the lymph node metastases 10 months postoperatively. The patient has received S-1 chemotherapy and remained in remission for more than 5 years 6 months.
我们描述了一名67岁男性，在接受减瘤手术后，因胃癌伴主动脉旁淋巴结转移接受S-1化疗，实现了长期完全缓解。该患者因上腹部疼痛前来我院就诊。他被诊断为胃癌伴主动脉旁淋巴结转移。我们进行了胃切除术和D1淋巴结清扫术，未对主动脉旁淋巴结转移灶进行任何切除。我们对患者进行了口服S-1化疗。初始治疗方案为100mg/体/天，每日两次，共4周，休息2周。在第二个疗程结束时出现了1级中性粒细胞减少。治疗方案改为给药2周，休息1周。主动脉旁淋巴结转移灶对化疗立即产生反应。术后10个月的腹部CT显示淋巴结转移灶几乎完全消退。该患者接受了S-1化疗，缓解期超过5年6个月。
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