Associations among oxidative stress, Lp-PLA activity and arterial stiffness according to blood pressure status at a 3.5-year follow-up in subjects with prehypertension.

BACKGROUND AND AIMS

We aimed to determine changes in oxidative stress, lipoprotein-associated phospholipase A (Lp-PLA) activity and arterial stiffness in subjects with persistent prehypertensive symptoms during a 3.5-year follow-up period.

METHODS

We divided 254 subjects with prehypertension according to their blood pressure (BP) status at 3.5 years of follow-up into three groups: reversed normotensive, persistent prehypertensive and developed hypertensive group. BP, serum lipid profile, oxidized LDL (ox-LDL), Lp-PLA activity and brachial-ankle pulse wave velocity (ba-PWV) were measured at baseline and the 3.5-year follow-up.

RESULTS

The reversed normotensive group showed a significant reduction in average BP (14.7/10.1 mmHg), whereas the developed hypertensive group showed a significant increase in average BP (15.2/11.5 mmHg). The persistent prehypertensive group showed increases in serum lipid profiles, circulating levels of Lp-PLA activity, ox-LDL and arterial stiffness as measured by ba-PWV at 3.5 years. The persistent prehypertensive and developed hypertensive groups showed greater increases in ox-LDL than the reversed normotensive group. The developed hypertensive group showed greater increases in Lp-PLA, 8-epi-PGF, and ba-PWV than those observed in the reversed normotensive and persistent prehypertensive groups. In all subjects, changes (Δ) in systolic blood pressure (SBP) positively correlated with Δ Lp-PLA, Δ ox-LDL, Δ urinary 8-epi-PGF and Δ ba-PWV.

CONCLUSIONS

This study indicates that in persistent prehypertension, increased ox-LDL hydrolysis by Lp-PLA enhances arterial stiffness without an age-related increase in BP.