通过在尿素熔体中热解柠檬酸轻松制备发光有机点及其用于细胞染色和聚电解质微胶囊标记的应用。
Facile fabrication of luminescent organic dots by thermolysis of citric acid in urea melt, and their use for cell staining and polyelectrolyte microcapsule labelling.
作者信息
Zholobak Nadezhda M, Popov Anton L, Shcherbakov Alexander B, Popova Nelly R, Guzyk Mykhailo M, Antonovich Valeriy P, Yegorova Alla V, Scrypynets Yuliya V, Leonenko Inna I, Baranchikov Alexander Ye, Ivanov Vladimir K
机构信息
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv 03680, Ukraine.
Institute of Theoretical and Experimental Biophysics, Pushchino 142290, Russia.
出版信息
Beilstein J Nanotechnol. 2016 Dec 2;7:1905-1917. doi: 10.3762/bjnano.7.182. eCollection 2016.
Luminescent organic dots (O-dots) were synthesized via a one-pot, solvent-free thermolysis of citric acid in urea melt. The influence of the ratio of the precursors and the duration of the process on the properties of the O-dots was established and a mechanism of their formation was hypothesized. The multicolour luminescence tunability and toxicity of synthesized O-dots were extensively studied. The possible applications of O-dots for alive/fixed cell staining and labelling of layer-by-layer polyelectrolyte microcapsules were evaluated.
通过将柠檬酸在尿素熔体中进行一锅无溶剂热解合成了发光有机点（O点）。确定了前驱体比例和过程持续时间对O点性质的影响，并推测了其形成机制。对合成的O点的多色发光可调性和毒性进行了广泛研究。评估了O点在活细胞/固定细胞染色以及逐层聚电解质微胶囊标记方面的潜在应用。
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