猿猴免疫缺陷病毒使滤泡辅助性T细胞和生发中心功能紊乱。
Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre.
作者信息
Lea-Henry Tom N, Jiang Simon H
机构信息
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia.
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia; ; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Acton, Australia.
出版信息
Ann Transl Med. 2016 Dec;4(24):520. doi: 10.21037/atm.2016.11.76.
Abstract
Yamamoto . have studied T follicular helper (T) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of T, reproducing infection-associated T accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate T and expression with superior antibody responses. Accumulation of T was accompanied by aberrant expression of non-T transcriptional regulators such as in T, suggesting viral induced abnormalities may affect T function.
摘要
山本等人研究了感染猿猴免疫缺陷病毒（SIV）的恒河猴（RM）感染后的T滤泡辅助细胞（Tfh）和生发中心（GC）反应。在这项研究中，作者检测了Tfh的行为，重现了与感染相关的Tfh积累及其与针对跨亚型病毒表位的抗体反应质量的关联。作者将Tfh和表达与优异的抗体反应相关联。Tfh的积累伴随着Tfh中非T转录调节因子如的异常表达，提示病毒诱导的异常可能影响Tfh功能。
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