Li Jie, Tian Xiaopeng, Wang Zhenze, Xiong Jiang, Fan Yubo, Deng Xiaoyan, Sun Anqiang, Liu Xiao
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
National Research Center for Rehabilitation Technical Aids, Beijing, China.
Biomed Eng Online. 2016 Dec 28;15(Suppl 2):135. doi: 10.1186/s12938-016-0249-z.
Abdominal aortic aneurysm (AAA) is a kind of dangerous aortic vascular disease, which is characterized by abdominal aorta partial enlargement. At present, endovascular aneurysm repair (EVAR) is one of the main treatments of abdominal aortic aneurysm. However for some patients after EVAR the aneurysm re-expanded and even ruptured, leading to poor postoperative effect. The stent-graft endoleak after EVAR was realized to influence the AAA in-sac pressure and contribute to the aneurysm re-enlargement.
In order to analyze the influence of endoleaks positions on the pressure shielding ability of stent-graft after EVAR, type I and type III endoleak models were reconstructed based on computed tomography (CT) scan images, and the hemodynamic environment in AAA was numerically simulated.
When the endoleak was at the proximal position the pressure shielding ability will be obviously weakened. While, the pressure shielding ability was higher in the systole phase than that in diastole phase when the endoleak located at the middle or distal positions. Unfortunately, when the endoleak located at the proximal position, the pressure shielding ability would be relatively weak in the whole cardiac cycle.
The results revealed that the influence of endoleaks on pressure shielding ability of stent-graft was both location and time specific.
腹主动脉瘤(AAA)是一种危险的主动脉血管疾病,其特征为腹主动脉局部扩张。目前,血管腔内修复术(EVAR)是腹主动脉瘤的主要治疗方法之一。然而,一些接受EVAR治疗后的患者动脉瘤会再次扩张甚至破裂,导致术后效果不佳。人们意识到EVAR术后的支架移植物内漏会影响腹主动脉瘤瘤腔内压力,并促使动脉瘤再次扩大。
为分析内漏位置对EVAR术后支架移植物压力屏蔽能力的影响,基于计算机断层扫描(CT)图像重建I型和III型内漏模型,并对腹主动脉瘤内的血流动力学环境进行数值模拟。
当内漏位于近端时,压力屏蔽能力会明显减弱。而当内漏位于中部或远端时,收缩期的压力屏蔽能力高于舒张期。遗憾的是,当内漏位于近端时,在整个心动周期中压力屏蔽能力相对较弱。
结果表明,内漏对支架移植物压力屏蔽能力的影响具有位置和时间特异性。