Association between ABCG2 and SLCO1B1 polymorphisms and adverse drug reactions to regorafenib: a preliminary study .

OBJECTIVE

Due to the occurrence of severe adverse drug reactions to regorafenib, a drug used in cancer therapy, the identification of a predictive marker(s) is needed to increase the therapeutic applicability of this compound. We therefore investigated whether polymorphisms in the and genes are associated with adverse drug reactions to regorafenib.

METHODS

For these analyses, 37 Japanese cancer patients were treated with regorafenib, genotyped for polymorphisms in and , and evaluated for drug-related adverse drug reactions.

RESULTS

There was no association between the 421C>A variant and adverse drug reactions to regorafenib. After treatment, the incidences of increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as well as increased total bilirubin (grade ≥ 2) were 8%, 4%, and 12%, and 42%, 25%, and 25% among carriers and non-carriers, respectively. There were no significant associations between elevated ALT and bilirubin and the allele. However, there were significantly lower incidences of increased AST (8% vs. 42%) and anemia (16% vs. 50%) in carriers than in non-carriers.

CONCLUSIONS: The absence of allele appears to be associated with the development of adverse drug reactions to regorafenib; however, further studies involving larger test groups and other populations are needed to confirm these findings.
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