日本口腔鳞状细胞癌复发风险因素患者术后放化疗治疗效果的回顾性研究。
Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence.
作者信息
Hasegawa Takumi, Yanamoto Souichi, Otsuru Mitsunobu, Yamada Shin-Ichi, Minamikawa Tsutomu, Shigeta Takashi, Naruse Tomofumi, Suzuki Takatsugu, Sasaki Masashi, Ota Yoshihide, Umeda Masahiro, Komori Takahide
机构信息
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 May;123(5):524-530. doi: 10.1016/j.oooo.2016.11.014. Epub 2016 Dec 7.
BACKGROUND
The purpose of this study was to investigate the feasibility of postoperative concomitant chemoradiotherapy (CRT) with cisplatin (CDDP), and compare the prognosis in 3 groups-without postoperative therapy (S-only), with radiotherapy (RT) alone (S+RT), and with CRT (S+CRT)-in oral squamous cell carcinoma (OSCC) patients at high risk of recurrence.
METHODS
Clinicopathologic data and treatment modality were investigated. Endpoints evaluated were locoregional control (LRC), relapse-free survival, overall survival (OS), and type of recurrence.
RESULTS
The S+CRT group was associated with a better LRC rate than the S-only (P < .001) and S+RT groups (P = .044). However, there was no significant difference in OS rates between the S+RT and S+CRT groups.
CONCLUSION
The addition of concomitant CDDP to postoperative RT improved LRC. However, there may be no benefit from the addition of concomitant CDDP to postoperative RT for improvement of distant metastasis and OS rates in OSCC patients.
背景
本研究旨在探讨术后顺铂同步放化疗（CRT）的可行性，并比较三组患者的预后，这三组分别为：未接受术后治疗（单纯手术组，S-only）、单纯放疗组（S+RT）和同步放化疗组（S+CRT），均为复发风险高的口腔鳞状细胞癌（OSCC）患者。
方法
对临床病理数据和治疗方式进行研究。评估的终点指标为局部区域控制（LRC）、无复发生存期、总生存期（OS）和复发类型。
结果
S+CRT组的LRC率优于单纯手术组（P <.001）和S+RT组（P =.044）。然而，S+RT组和S+CRT组的OS率无显著差异。
结论
术后放疗联合顺铂可提高LRC。然而，对于OSCC患者，术后放疗联合顺铂可能无助于改善远处转移和提高OS率。
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