Sezeur A, Kracht M, Rey P, Leandri J, Fagniez P L, Farah A, Julien M, Malafosse M
Ann Chir. 1989;43(6):421-4.
Thirty patients with high biliary tract strictures were treated by a new surgical endoprosthesis, the tolerance of which has been tested experimentally. It is flexible, radiopaque and incompressible with spurs which prevent migration. Following choledochotomy, the endoprosthesis is positioned surgically above the sphincter of Oddi, thereby avoiding ascending cholangitis. Twenty-nine cases presented with neoplastic compression by an inoperable cancer and one case had an early postoperative stricture with loss of substance after right hepatectomy for hepatic metastases. The 29 cancers included 13 gallbladder cancers, 11 cholangiocarcinomas, 10 of which were hilar, and 5 metastatic compressions due to gastrointestinal adenocarcinomas. In three cases, there was loss of substance of biliary tract after intubation. The operative mortality was 3.3% (one pulmonary complication). Resolution of jaundice was obtained in all but 2 cases and pruritus always resolved. The mean survival of the patients with cholangiocarcinoma was 12.2 months while that of patients with gallbladder cancer was 6.33 months with indices of satisfaction, calculated by Bismuth's method, varying between 71% (gallbladder cancer) and 93.5% (hilar cholangiocarcinoma). The patient operated for benign stricture secondary to a hepatectomy scar for metastases died from lung metastases without jaundice after 48 months. The only late complications were 2 cases of cholangitis treated medically, one of which was due to obstruction of the endoprosthesis at the 13th month. The authors conclude that this new type of surgical endoprosthesis constitutes an alternative in the palliative treatment of neoplastic hilar compressions.
30例高位胆道狭窄患者接受了一种新型手术内置假体治疗,该假体的耐受性已通过实验测试。它具有柔韧性、不透X线且不可压缩,带有防止移位的棘刺。在胆总管切开术后,通过手术将内置假体置于Oddi括约肌上方,从而避免上行性胆管炎。29例患者因无法手术切除的癌症出现肿瘤压迫,1例患者在因肝转移行右肝切除术后早期出现吻合口狭窄并伴有组织缺失。29例癌症包括13例胆囊癌、11例胆管癌,其中10例为肝门部胆管癌,以及5例因胃肠道腺癌导致的转移性压迫。3例患者插管后出现胆道组织缺失。手术死亡率为3.3%(1例肺部并发症)。除2例患者外,所有患者黄疸均消退,瘙痒也总是能够缓解。胆管癌患者的平均生存期为12.2个月,胆囊癌患者为6.33个月,采用Bismuth方法计算的满意度指数在71%(胆囊癌)至93.5%(肝门部胆管癌)之间。因肝转移切除术后肝切除瘢痕继发良性狭窄而接受手术的患者在48个月后死于肺转移,无黄疸。仅有的晚期并发症为2例经药物治疗的胆管炎,其中1例是由于第13个月时内置假体阻塞所致。作者得出结论,这种新型手术内置假体是肿瘤性肝门部压迫姑息治疗的一种替代方法。