Beilfuss Julia, Camargo Carlos A, Kamycheva Elena
Endocrine Research Group, Faculty of Health Sciences, Department of Clinical Medicine, University of Tromsoe-The Arctic University of Norway, Tromsoe, Norway.
Medical Clinic, University Hospital of North Norway, Tromsoe, Norway.
J Nutr. 2017 Apr;147(4):514-520. doi: 10.3945/jn.116.244137. Epub 2017 Feb 8.
Vitamin D deficiency has been linked to all-cause mortality and cancer. However, the biological plausibility of these associations is not well established. Leukocyte telomere length (LTL) shortening is associated with aging and is a hallmark of genomic instability and carcinogenesis. We aimed to investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and LTL in the general US population. We analyzed data from the US NHANES 2001-2002. The study population comprised 1542 younger adults (aged 20-39 y), 1336 middle-aged adults (aged 40-59 y), and 1382 older adults (aged ≥60 y). LTL was measured by using quantitative polymerase chain reaction. Serum 25(OH)D concentrations ≥50 nmol/L were considered optimal. Linear regression, adjusted for age, sex, race/ethnicity, body mass index (BMI), total energy and sugar intakes, calcium intake, socioeconomic status, milk and dietary supplement consumption, and physical activity, was applied to investigate the association between serum 25(OH)D and LTL. In the total population, age, sex, BMI, and non-Hispanic black race/ethnicity were significant predictors of LTL. In the participants aged 40-59 y, an increment in serum 25(OH)D of 10 nmol/L was associated with a 0.03- ± 0.01-kbp longer LTL, adjusted for age, sex, race/ethnicity, and other factors ( = 0.001). In the same age group, 25(OH)D concentrations ≥50 nmol/L were associated with a 0.13- ± 0.04-kbp longer LTL than those for 25(OH)D concentrations <50 nmol/L ( = 0.01). The association was independent of age, sex, race/ethnicity, BMI, and other factors. In a nationally representative population of adults, serum 25(OH)D was positively associated with LTL in middle-aged participants (aged 40-59 y), independently of other factors. These findings suggest that decreased 25(OH)D concentrations are associated with genomic instability, although the clinical impact of this observation remains unclear.
维生素D缺乏与全因死亡率及癌症相关。然而，这些关联的生物学合理性尚未得到充分证实。白细胞端粒长度（LTL）缩短与衰老相关，是基因组不稳定和致癌作用的一个标志。我们旨在研究美国普通人群中血清25-羟基维生素D [25(OH)D] 浓度与LTL之间的关联。我们分析了来自美国2001 - 2002年国家健康与营养检查调查（NHANES）的数据。研究人群包括1542名年轻成年人（20 - 39岁）、1336名中年成年人（40 - 59岁）和1382名老年人（≥60岁）。LTL通过定量聚合酶链反应进行测量。血清25(OH)D浓度≥50 nmol/L被视为最佳水平。应用线性回归，对年龄、性别、种族/民族、体重指数（BMI）、总能量和糖摄入量、钙摄入量、社会经济地位、牛奶和膳食补充剂消费以及身体活动进行校正，以研究血清25(OH)D与LTL之间的关联。在总体人群中，年龄、性别、BMI和非西班牙裔黑人种族/民族是LTL的显著预测因素。在40 - 59岁的参与者中，血清25(OH)D每增加10 nmol/L，在对年龄、性别、种族/民族和其他因素进行校正后，LTL延长0.03 ± 0.01 kbp（P = 0.001）。在同一年龄组中，25(OH)D浓度≥50 nmol/L者的LTL比25(OH)D浓度<50 nmol/L者长0.13 ± 0.04 kbp（P = 0.01）。该关联独立于年龄、性别、种族/民族、BMI和其他因素。在具有全国代表性的成年人群中，中年参与者（40 - 59岁）的血清25(OH)D与LTL呈正相关，且独立于其他因素。这些发现表明，25(OH)D浓度降低与基因组不稳定相关，尽管这一观察结果的临床影响仍不清楚。
