合成（聚合物）生物学（膜）：用于膜蛋白的聚合物支架功能化
Synthetic (polymer) biology (membrane): functionalization of polymer scaffolds for membrane proteins.
作者信息
Hu Zhaolong, Ho James C S, Nallani Madhavan
机构信息
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore; ACM Biolabs Pte Ltd., Innovation Centre Block 2, 18 Nanyang Drive, 637723, Singapore.
出版信息
Curr Opin Biotechnol. 2017 Aug;46:51-56. doi: 10.1016/j.copbio.2016.10.012. Epub 2017 Feb 7.
A plethora of polymer-based scaffolds have been designed to facilitate biochemical and biophysical investigation of membrane proteins, with a common goal to stabilize and present them in a functional format. In this review, an up-to-date account of such polymer-based supports and incorporation methodologies are presented. Furthermore, conceptual and imminent technological advances, with associated technical challenges are proposed.
人们已经设计出大量基于聚合物的支架，以促进对膜蛋白的生化和生物物理研究，其共同目标是以功能形式稳定并呈现膜蛋白。在本综述中，将对这类基于聚合物的载体及其掺入方法进行最新介绍。此外，还提出了概念性和即将出现的技术进步以及相关的技术挑战。
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