将强效细胞毒性治疗药物封装于白蛋白纳米颗粒中可实现药物的持续释放，并减轻癌症药物的毒性。
Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity.
作者信息
Wang Hangxiang, Wu Jiaping, Xu Li, Xie Ke, Chen Chao, Dong Yuehan
机构信息
The First Affiliated Hospital, School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, P. R. China.
College of Life Sciences, Huzhou University, Huzhou, 313000, P. R. China.
出版信息
Chem Commun (Camb). 2017 Feb 23;53(17):2618-2621. doi: 10.1039/c6cc08978j.
We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.
我们在此首次报告了利用白蛋白构建载有高效细胞毒性治疗药物的纳米颗粒。美登素类药物DM1能够有效地整合到白蛋白纳米颗粒中，从而显著减轻体内药物毒性，并拓展了可用于癌症治疗的白蛋白技术种类。
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