多细胞球体形成的进展。
Advances in multicellular spheroids formation.
作者信息
Cui X, Hartanto Y, Zhang H
机构信息
School of Chemical Engineering, University of Adelaide, Adelaide, South Australia 5005, Australia.
School of Chemical Engineering, University of Adelaide, Adelaide, South Australia 5005, Australia
出版信息
J R Soc Interface. 2017 Feb;14(127). doi: 10.1098/rsif.2016.0877.
Abstract
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell-cell/cell-matrix interactions and bio-mimicking microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the and model. In this review paper, we discussed the structure and biology of MCSs and detailed fabricating methods. Among these methods, the approach in microfluidics with hydrogel support for MCS formation is promising because it allows essential cell-cell/cell-matrix interactions in a confined space.
摘要
三维多细胞球体（MCSs）具有复杂的结构架构、动态的细胞间/细胞与基质相互作用以及生物模拟微环境。作为组织重建的基本构建单元，MCSs已成为一种有力工具，以缩小[此处原文缺失两个关键信息]模型之间的差距。在这篇综述文章中，我们讨论了MCSs的结构与生物学特性以及详细的制备方法。在这些方法中，利用水凝胶支持在微流控中形成MCSs的方法很有前景，因为它能在受限空间内实现关键的细胞间/细胞与基质相互作用。
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