惊恐发作患者血小板的3H-萝芙辛结合情况。

Platelet 3H-rauwolscine binding in patients with panic attacks.

作者信息

Norman T R, Kimber N M, Judd F K, Burrows G D, McIntyre I M

机构信息

Department of Psychiatry, University of Melbourne, Victoria, Australia.

出版信息

Psychiatry Res. 1987 Sep;22(1):43-8. doi: 10.1016/0165-1781(87)90049-7.

DOI:10.1016/0165-1781(87)90049-7

PMID:2821567

Abstract

Platelet alpha 2 binding was measured in 14 patients with panic attacks and 21 controls using the antagonist 3H-rauwolscine as radioligand. The mean (+/- SD) Bmax values of patients (116 +/- 45 fmoles/mg protein) and controls (106 +/- 32 fmoles/mg protein) was not significantly different (p greater than 0.05, Mann-Whitney U test). There was a nonsignificant trend for the Kd of patients (1.25 +/- 0.67 nM) to be higher than that of controls (0.96 +/- 0.32 nM). The results do not support an adrenergic abnormality in panic patients.

摘要

使用拮抗剂3H-萝芙辛作为放射性配体，对14名惊恐发作患者和21名对照者进行血小板α2结合检测。患者组的平均（±标准差）Bmax值为（116±45飞摩尔/毫克蛋白），对照组为（106±32飞摩尔/毫克蛋白），差异无统计学意义（p＞0.05，曼-惠特尼U检验）。患者组的Kd值（1.25±0.67纳摩尔）有高于对照组（0.96±0.32纳摩尔）的趋势，但差异无统计学意义。研究结果不支持惊恐症患者存在肾上腺素能异常。