分子氢：一种具有治疗作用的抗氧化剂及其他功效
Molecular hydrogen: a therapeutic antioxidant and beyond.
作者信息
Huang Lei
机构信息
Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA; Department of Basic Sciences, Division of Physiology, Loma Linda University, Loma Linda, CA, USA.
出版信息
Med Gas Res. 2016 Dec 30;6(4):219-222. doi: 10.4103/2045-9912.196904. eCollection 2016 Oct-Dec.
Abstract
Molecular hydrogen (H) medicine research has flourished since a landmark publication in that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients.
摘要
自2007年一篇具有里程碑意义的论文发表以来，分子氢（H₂）医学研究蓬勃发展，该论文揭示了氢气在局灶性中风模型中的抗氧化和细胞保护作用。越来越多的证据一致表明，分子氢是治疗多种疾病的一种有前景的治疗选择，其潜在的综合机制不仅仅是单纯的清除羟基自由基。分子氢在高浓度下的无毒特性和快速的细胞扩散特性确保了其向人类患者进行临床转化的可行性和可操作性。 （注：原文中“since a landmark publication in that”表述有误，推测应该是“since a landmark publication in 2007”之类，这里按照合理推测进行了翻译调整）
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