Robin E, Guieu L V, Le Boedec K
Internal Medicine Unit, CHV Fregis, Arcueil, France.
Emergency and Critical Care Unit, CHV Fregis, Arcueil, France.
J Vet Intern Med. 2017 Mar;31(2):550-555. doi: 10.1111/jvim.14650. Epub 2017 Feb 22.
Endotracheal intubation is a common procedure, rarely associated with life-threatening complications (e.g., tracheal rupture, necrosis, foreign body). A 1.5-year-old English Bulldog was presented for respiratory distress, with increased respiratory efforts and stridor, 2 days after endotracheal intubation. Cervical and thoracic radiographs disclosed a severe narrowing of the tracheal lumen associated with an intraluminal soft-tissue structure at the thoracic inlet. Tracheoscopy confirmed the presence of an obstructive fibrinous tracheal pseudomembrane (OFTP) creating a 1-way valve obstruction. Removal of the OFTP dramatically improved the dog's respiratory function, but the lesion reformed twice despite corticosteroid and antibiotic therapy PO, warranting repeated endoscopic removal of the OFTP. No additional recurrences were observed after treatment with inhaled heparin and N-acetylcysteine q4h. No respiratory signs were reported 9 months after discharge. Postintubation OFTP has been reported rarely in humans and never described in dogs. Unexplained signs of upper airway obstruction shortly after endotracheal intubation should prompt consideration of OFTP in dogs, even if intubation was uneventful. Unlike its counterpart in humans, OFTP in dogs can reoccur after endoscopic removal, warranting repeated endoscopic extraction. A combination of corticosteroid therapy PO and heparin and N-acetylcysteine inhalation q4h may be attempted if recurrence is observed.
气管插管是一种常见的操作,很少会引发危及生命的并发症(如气管破裂、坏死、异物)。一只1.5岁的英国斗牛犬在气管插管2天后因呼吸窘迫前来就诊,表现为呼吸用力增加和喘鸣。颈部和胸部X光片显示气管腔严重狭窄,与胸段入口处的腔内软组织结构有关。气管镜检查证实存在阻塞性纤维性气管假膜(OFTP),形成单向瓣膜阻塞。去除OFTP后,狗狗的呼吸功能显著改善,但尽管口服了皮质类固醇和抗生素治疗,病变仍两次复发,因此需要反复通过内镜去除OFTP。吸入肝素和N-乙酰半胱氨酸每4小时一次治疗后未观察到再次复发。出院9个月后未报告有呼吸症状。插管后OFTP在人类中很少有报道,在犬类中从未有过描述。气管插管后不久出现不明原因的上呼吸道梗阻症状时,即使插管过程顺利,也应考虑犬类发生OFTP的可能性。与人类不同,犬类的OFTP在内镜切除后可能会复发,因此需要反复进行内镜摘除。如果观察到复发,可以尝试口服皮质类固醇治疗以及每4小时吸入肝素和N-乙酰半胱氨酸的联合治疗。