Hildebrandt Tom, Epstein Elizabeth E, Sysko Robyn, Bux Donald A
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York.
Center of Alcohol Studies, Rutgers - The State University of New Jersey, Piscataway, New Jersey.
Alcohol Clin Exp Res. 2017 May;41(5):987-997. doi: 10.1111/acer.13367. Epub 2017 Mar 30.
The type A/B classification model for alcohol use disorders (AUDs) has received considerable empirical support. However, few studies examine the underlying latent structure of this subtyping model, which has been challenged as a dichotomization of a single drinking severity dimension. Type B, relative to type A, alcoholics represent those with early age of onset, greater familial risk, and worse outcomes from alcohol use.
We examined the latent structure of the type A/B model using categorical, dimensional, and factor mixture models in a mixed-gender community treatment-seeking sample of adults with an AUD.
Factor analytic models identified 2 factors (drinking severity/externalizing psychopathology and internalizing psychopathology) underlying the type A/B indicators. A factor mixture model with 2 dimensions and 3 classes emerged as the best overall fitting model. The classes reflected a type A class and 2 type B classes (B1 and B2) that differed on the respective level of drinking severity/externalizing pathology and internalizing pathology. Type B1 had a greater prevalence of women and more internalizing pathology and B2 had a greater prevalence of men and more drinking severity/externalizing pathology. The 2-factor, 3-class model also exhibited predictive validity by explaining significant variance in 12-month drinking and drug use outcomes.
The model identified in this study may provide a basis for examining different sources of heterogeneity in the course and outcome of AUDs.
酒精使用障碍(AUDs)的A/B型分类模型已获得大量实证支持。然而,很少有研究考察这种亚型分类模型的潜在潜在结构,该模型作为单一饮酒严重程度维度的二分法受到了挑战。相对于A型酗酒者,B型酗酒者代表那些发病年龄早、家族风险更高且饮酒后果更差的人。
我们在一个寻求社区治疗的成年AUD患者的混合性别样本中,使用分类模型、维度模型和因子混合模型来考察A/B型模型的潜在结构。
因子分析模型确定了A/B型指标背后的2个因子(饮酒严重程度/外化精神病理学和内化精神病理学)。一个具有2个维度和3个类别的因子混合模型成为总体拟合最佳的模型。这些类别反映了一个A型类别和2个B型类别(B1和B2),它们在饮酒严重程度/外化病理学和内化病理学的各自水平上有所不同。B1型女性患病率更高,内化病理学更多,而B2型男性患病率更高,饮酒严重程度/外化病理学更多。这个2因子、3类别模型通过解释12个月饮酒和药物使用结果中的显著方差,也表现出预测效度。
本研究中确定的模型可能为检查AUDs病程和结果中不同的异质性来源提供基础。