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用于Churg-Strauss综合征流行病学研究的医院发病率数据库。

Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome.

作者信息

Kanecki Krzysztof, Nitsch-Osuch Aneta, Gorynski Paweł, Tarka Patryk, Tyszko Piotr

机构信息

Department of Social Medicine and Public Health, Medical University of Warsaw, Oczki Str. 3, 02-007, Warsaw, Poland.

National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-971, Warsaw, Poland.

出版信息

Adv Exp Med Biol. 2017;980:19-25. doi: 10.1007/5584_2017_8.

Abstract

Churg-Strauss syndrome or more accurately eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel necrotizing vasculitis with a characteristic late-onset allergic rhinitis and asthma. The use of hospital morbidity database is an important element of the epidemiological analysis of this rare disease. The present study was undertaken to assess the incidence of EGPA and factors related to its epidemiology in Poland; the first analysis of the kind in Poland, enabling a comparison in the European context. This is a retrospective, population-based study using hospital discharge records with EGPA diagnosis, collected for a National Institute of Public Health survey covering the period from 2008 to 2013. The group consisted of 344 patients (206 females and 138 males) with the first-time hospitalization for EGPA. The major findings are that the annual incidence of EGPA in Poland was 1.5 per million (95% confidence intervals: 1.2-1.8), with the point prevalence of 8.8 per million at the end of 2013. A greater incidence of EGPA was observed in the regions with urban predominance. We conclude that discharge records may be a useful element of epidemiological studies on EGPA.

摘要

变应性肉芽肿性血管炎(Churg-Strauss综合征,或更准确地称为嗜酸性肉芽肿性多血管炎(EGPA))是一种小血管坏死性血管炎,其特征为迟发性变应性鼻炎和哮喘。利用医院发病率数据库是对这种罕见疾病进行流行病学分析的重要环节。本研究旨在评估波兰EGPA的发病率及其相关的流行病学因素;这是波兰首次进行此类分析,从而能够在欧洲范围内进行比较。这是一项基于人群的回顾性研究,使用了2008年至2013年期间为国家公共卫生研究所调查收集的、诊断为EGPA的医院出院记录。该组包括344例首次因EGPA住院的患者(206例女性和138例男性)。主要研究结果是,波兰EGPA的年发病率为每百万人口1.5例(95%置信区间:1.2 - 1.8),到2013年底的时点患病率为每百万人口8.8例。在以城市为主的地区观察到EGPA的发病率更高。我们得出结论,出院记录可能是EGPA流行病学研究的一个有用元素。

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