心血管系统中的水通道蛋白。

Aquaporins in Cardiovascular System.

作者信息

Tie Lu, Wang Di, Shi Yundi, Li Xuejun

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.

Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.

出版信息

Adv Exp Med Biol. 2017;969:105-113. doi: 10.1007/978-94-024-1057-0_6.

DOI:10.1007/978-94-024-1057-0_6

PMID:28258568

Abstract

Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases. Here we will discuss the expression and physiological function of AQPs in cardiovascular system and summarize recent researches on AQPs related cardiovascular diseases.

摘要

最近的研究表明，一些水通道蛋白（AQP），包括AQP1、AQP4、AQP7和AQP9，在心血管系统的内皮细胞、血管平滑肌细胞和心脏中表达。这些水通道蛋白参与心血管功能以及相关疾病的病理过程，如脑缺血、充血性心力衰竭、高血压和血管生成。因此，了解水通道蛋白与心血管系统之间的准确关联非常重要，这可能为预防和治疗相关疾病提供新的方法。在此，我们将讨论水通道蛋白在心血管系统中的表达和生理功能，并总结最近关于水通道蛋白相关心血管疾病的研究。