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流感后曲霉病,不要低估乙型流感。

Post-influenza aspergillosis, do not underestimate influenza B.

作者信息

Nulens Eric Fl, Bourgeois Marc Jc, Reynders Marijke Bml

机构信息

Laboratory Medicine, Medical Microbiology.

Department of Intensive Care, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Brugge, Belgium.

出版信息

Infect Drug Resist. 2017 Feb 21;10:61-67. doi: 10.2147/IDR.S122390. eCollection 2017.

Abstract

Our objective is to highlight and focus on post-influenza aspergillosis, triggered by influenza B virus. This relatively new clinical entity is often associated with a fulminant course of respiratory decline and high mortality. A 51-year immunocompetent woman, without any medical history or risk factors for developing a complicated influenza infection, was admitted to the intensive care unit. During admission, she presented with an afebrile flu-like syndrome, myocarditis, rhabdomyolysis, multiple organ failure, and evolved to severe respiratory distress. The broncho-alveolar lavage contained influenza B RNA, and the culture revealed . Despite maximal organ support, immunoglobulin, antiviral and antifungal therapy, the patient died. This case demonstrates that influenza B virus may be life threatening even to immunocompetent adults and may trigger an invasive superinfection.

摘要

我们的目标是突出并聚焦由乙型流感病毒引发的流感后曲霉病。这种相对较新的临床病症通常与呼吸功能迅速衰退和高死亡率相关。一名51岁免疫功能正常的女性,没有任何病史或发生复杂流感感染的风险因素,被收入重症监护病房。入院期间,她表现出无发热的流感样综合征、心肌炎、横纹肌溶解、多器官功能衰竭,并发展为严重的呼吸窘迫。支气管肺泡灌洗检测出乙型流感病毒RNA,培养结果显示……尽管给予了最大程度的器官支持、免疫球蛋白、抗病毒和抗真菌治疗,患者仍死亡。该病例表明,乙型流感病毒即使对免疫功能正常的成年人也可能危及生命,并可能引发侵袭性二重感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e75/5330186/85ea6abedbfc/idr-10-061Fig1.jpg

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