Miśkowiak B, Kasprzak A, Malendowicz L K
Department of Histology and Embryology, Poznań Academy of Medicine, Poland.
J Anat. 1986 Jun;146:167-72.
The aim of the study was to investigate by means of stereological and biochemical methods the effects of long-term CRF administration on the cortex of the suprarenal gland of adult male rats and to compare these effects with those of ACTH. Both CRF (administered into the lateral ventricle of the brain) and ACTH resulted after 8 days in an increase in weight of the suprarenal gland. Both treatments increased the volume of individual adrenocortical zones and the average volume of adrenocortical cells as well as enhancing the total number of parenchymal cells in the paired glands. There was also no significant difference in those functional parameters studied of the adrenocortical cells of CRF- and ACTH-treated rats. Thus, long term treatment of adult male rats with CRF evoked adrenocortical changes similar to those observed after ACTH administration.
本研究的目的是通过体视学和生化方法,研究长期给予促肾上腺皮质激素释放因子(CRF)对成年雄性大鼠肾上腺皮质的影响,并将这些影响与促肾上腺皮质激素(ACTH)的影响进行比较。给予CRF(注入脑侧脑室)和ACTH 8天后,肾上腺重量均增加。两种处理均增加了各个肾上腺皮质区的体积和肾上腺皮质细胞的平均体积,同时增加了双侧肾上腺实质细胞的总数。在CRF和ACTH处理的大鼠肾上腺皮质细胞的这些功能参数研究中也没有显著差异。因此,成年雄性大鼠长期接受CRF治疗会引起与给予ACTH后观察到的类似的肾上腺皮质变化。