单份非支气管镜下支气管肺泡灌洗术在犬转移性乳腺肿瘤诊断中的应用
Single-aliquot, non-bronchoscopic bronchoalveolar lavage in the diagnosis of metastatic mammary tumours in dogs.
作者信息
Pavelski M, Correa Leite N, Pedri E, Guérios S D, De Sousa R S, Rodrigues Froes T, Triches Dornbusch P
机构信息
Department of Veterinary Medicine, Federal University of Parana, Curitiba, PR, 80060-000, Brazil.
出版信息
J Small Anim Pract. 2017 Mar;58(3):168-173. doi: 10.1111/jsap.12609.
OBJECTIVE
To evaluate the use of bronchoalveolar lavage as an auxiliary tool for the diagnosis of neoplastic lung metastasis from mammary tumours in dogs.
METHODS
A single-institution prospective observational study including 20 healthy dogs and 30 with mammary tumours. Thoracic radiography and single-aliquot, non-bronchoscopic bronchoalveolar lavage with cytology interpretation was performed in all animals and the results compared between groups.
RESULTS
Dogs with mammary gland tumours and radiographic evidence of pulmonary metastasis had significantly higher relative neutrophil counts in bronchoalveolar lavage fluid than dogs with tumours without evidence of metastasis. In only one dog, in which thoracic radiographs were normal, were malignant cells identified in bronchoalveolar lavage fluid.
CLINICAL SIGNIFICANCE
Inflammatory bronchoalveolar lavage fluid in dogs with mammary gland tumours may suggest metastatic disease. Bronchoalveolar lavage does not appear to be sensitive for identifying malignant cells.
目的
评估支气管肺泡灌洗作为诊断犬乳腺肿瘤肺转移的辅助工具的应用。
方法
一项单机构前瞻性观察研究，纳入20只健康犬和30只患有乳腺肿瘤的犬。对所有动物进行胸部X线摄影以及单份、非支气管镜下支气管肺泡灌洗并进行细胞学解读，比较两组结果。
结果
有乳腺肿瘤且有肺部转移影像学证据的犬，其支气管肺泡灌洗液中的相对中性粒细胞计数显著高于无转移证据的肿瘤犬。仅在1只胸部X线片正常的犬的支气管肺泡灌洗液中发现了恶性细胞。
临床意义
患有乳腺肿瘤的犬出现炎性支气管肺泡灌洗液可能提示转移性疾病。支气管肺泡灌洗在识别恶性细胞方面似乎不敏感。
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