[交联对角膜上皮愈合的影响]

[Impact of crosslinking on corneal epithelial healing].

作者信息

Gyenes Andrea, Szentmáry Nóra, Tóth Gábor, Kiss Huba, Szekrényesi Csaba, Langenbucher Achim, Nagy Zoltán Zsolt

机构信息

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária utca 39., 1085.

Klinik für Augenheilkunde, Universität des Saarlandes, UKS Homburg/Saar.

出版信息

Orv Hetil. 2017 Mar;158(10):376-379. doi: 10.1556/650.2017.30669.

DOI:10.1556/650.2017.30669

PMID:28270007

Abstract

INTRODUCTION AND AIM

To analyse the effect of crosslinking (CXL) on corneal epithelial healing.

PATIENTS AND METHOD

39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients. These data were compared using chi-quadrat test.

RESULTS

Following crosslinking, epithelial closure occured within 3, following PRK within 4 days. In the area of epithelial erosion 45 and 69 hours after CXL or PRK treatment statistically significant difference (p = 0.005 and p<0.001) was verified.

CONCLUSION

Our results show beneficial effect of crosslinking on corneal epithelial healing. Orv. Hetil., 2017, 158(10), 376-379.

摘要

引言与目的

分析交联（CXL）对角膜上皮愈合的影响。

患者与方法

本研究纳入39例接受CXL治疗的圆锥角膜患者和11例接受PRK治疗的患者。在CXL治疗后21、45和69小时以及PRK治疗后16、37和61小时，使用荧光素染色拍摄裂隙灯照片，并确定上皮缺损的大小和上皮闭合的时间。由于两组的观察时间点不同，因此计算了PRK治疗后上皮缺损的大小，用于分析CXL患者的时间点。使用卡方检验对这些数据进行比较。