脑磁共振成像在帕金森综合征诊断检查中的临床应用
Clinical Application of Brain MRI in the Diagnostic Work-up of Parkinsonism.
作者信息
Meijer Frederick J A, Goraj Bozena, Bloem Bastiaan R, Esselink Rianne A J
机构信息
Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Diagnostic Imaging, Medical Center of Postgraduate Education, Warsaw, Poland.
出版信息
J Parkinsons Dis. 2017;7(2):211-217. doi: 10.3233/JPD-150733.
BACKGROUND
Differentiating Parkinson's disease and atypical parkinsonism on clinical parameters is challenging, especially in early disease courses. This is due to large overlap in symptoms and because the so called red flags, i.e. symptoms indicating atypical parkinsonism, have not (fully) developed. Brain MRI can aid to improve the accuracy and confidence about the diagnosis.
OBJECTIVE AND METHODS
In the current paper, we discuss when brain MRI should be performed in the diagnostic work-up of parkinsonism, our preferred brain MRI scanning protocol, and the diagnostic value of specific abnormalities.
RESULTS AND CONCLUSIONS
The main purpose of brain MRI is to assess cerebrovascular damage, and to exclude other possible - and sometimes treatable - causes of parkinsonism, such as normal pressure hydrocephalus. Furthermore, brain MRI can support the possible or probable diagnosis of a specific form of atypical parkinsonism.
背景
根据临床参数区分帕金森病和非典型帕金森综合征具有挑战性，尤其是在疾病早期阶段。这是因为症状存在大量重叠，且所谓的警示信号，即表明非典型帕金森综合征的症状尚未（完全）显现。脑部磁共振成像（MRI）有助于提高诊断的准确性和可信度。
目的与方法
在本文中，我们讨论了在帕金森综合征的诊断检查中何时应进行脑部MRI检查、我们首选的脑部MRI扫描方案以及特定异常的诊断价值。
结果与结论
脑部MRI的主要目的是评估脑血管损伤，并排除帕金森综合征的其他可能（且有时可治疗）的病因，如正常压力脑积水。此外，脑部MRI可支持对特定形式的非典型帕金森综合征进行可能或很可能的诊断。
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