Iwaoka T, Nugent C A, Umeda T, Sato T
Third Department of Internal Medicine, Kumamoto University Medical School, Japan.
Jpn Heart J. 1987 Sep;28(5):695-705. doi: 10.1536/ihj.28.695.
White blood cell (WBC) Na+ and K+ concentrations, plasma (Na+ + K+)ATPase inhibition and blood pressure were determined in normotensive control subjects and patients with essential hypertension. While the untreated hypertensive group had significantly lower WBC K+ concentrations than the normotensive group (mean +/- SEM, 121.6 +/- 4.4 vs. 134.7 +/- 2.8 mEq/kg, p less than 0.05), no significant difference was observed in WBC Na+ concentrations between the 2 groups. The mean of plasma (Na+ + K+)-ATPase inhibition in untreated hypertensive patients was higher than that in normotensive controls (14.8 +/- 1.7 vs. 7.2 +/- 1.8%, p less than 0.05). The correlations between (Na+ + K+)ATPase inhibition and mean blood pressure and between WBC Na+/K+ ratio and mean blood pressure were significant (r = 0.278, p less than 0.05 and 0.270, p less than 0.05, respectively), but both were weak. However, untreated hypertensive patients with higher (Na+ + K+)ATPase inhibition had significantly higher WBC Na+/K+ ratios than untreated patients with less (Na+ + K+)ATPase inhibition. These results suggest a contribution of plasma (Na+ + K+)ATPase inhibition in the production of high blood pressure in a subset of patients with essential hypertension, which results in altered intracellular K+ concentrations.
在血压正常的对照受试者和原发性高血压患者中测定了白细胞（WBC）的钠和钾浓度、血浆（钠 + 钾）ATP酶抑制情况以及血压。未经治疗的高血压组白细胞钾浓度显著低于血压正常组（均值±标准误，121.6±4.4 对 134.7±2.8 mEq/kg，p＜0.05），两组间白细胞钠浓度未观察到显著差异。未经治疗的高血压患者血浆（钠 + 钾）-ATP酶抑制的均值高于血压正常的对照组（14.8±1.7 对 7.2±1.8%，p＜0.05）。（钠 + 钾）ATP酶抑制与平均血压之间以及白细胞钠/钾比值与平均血压之间的相关性显著（r = 0.278，p＜0.05 和 0.270，p＜0.05），但两者均较弱。然而，（钠 + 钾）ATP酶抑制较高的未经治疗的高血压患者白细胞钠/钾比值显著高于（钠 + 钾）ATP酶抑制较低的未经治疗的患者。这些结果表明，血浆（钠 + 钾）ATP酶抑制在一部分原发性高血压患者的高血压产生中起作用，这导致细胞内钾浓度改变。
