Nazem-Zadeh Mohammad R, Bowyer Susan M, Moran John E, Davoodi-Bojd Esmaeil, Zillgitt Andrew, Bagher-Ebadian Hassan, Mahmoudi Fariborz, Elisevich Kost V, Soltanian-Zadeh Hamid
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:5925-5928. doi: 10.1109/EMBC.2016.7592077.
Magnetoencephalography (MEG) is a noninvasive imaging method for localization of focal epileptiform activity in patients with epilepsy. This study investigates the cerebral functional abnormalities quantified by MEG coherence laterality in mesial temporal lobe epilepsy (mTLE). Resting state MEG data was analyzed using MEG coherence source imaging (MEG-CSI) method to determine the coherence in 54 anatomical sites in 12 adult mTLE patients and 12 age- and gender-matched controls. MEG coherence laterality, after Bonferroni adjustment, showed significant differences for right versus left mTLE in insular cortex and both lateral orbitofrontal and superior temporal gyri (p<;0.025). None of these anatomical sites showed statistically significant differences in coherence laterality between right and left sides of controls. Coherence laterality was in agreement with the declared side of epileptogenicity in insular cortex (in 75% of patients) and both lateral orbitofrontal (83%) and superior temporal gyri (84%). Combining all significant laterality indices improved the lateralization accuracy to 92%. The proposed methodology for using MEG to investigate the abnormalities related to focal epileptogenicity and propagation can provide a further means of noninvasive lateralization.
脑磁图（MEG）是一种用于定位癫痫患者局灶性癫痫样活动的非侵入性成像方法。本研究调查了内侧颞叶癫痫（mTLE）中通过MEG相干性偏侧化量化的脑功能异常。使用MEG相干源成像（MEG-CSI）方法分析静息态MEG数据，以确定12例成年mTLE患者和12例年龄及性别匹配的对照者54个解剖部位的相干性。经Bonferroni校正后，MEG相干性偏侧化显示，岛叶皮质以及双侧眶额外侧回和颞上回中，右侧与左侧mTLE存在显著差异（p<0.025）。在这些解剖部位中，对照组左右两侧的相干性偏侧化均未显示出统计学上的显著差异。在岛叶皮质（75%的患者）、双侧眶额外侧回（83%）和颞上回（84%）中，相干性偏侧化与所宣称的致痫侧一致。综合所有显著的偏侧化指标可将定位准确性提高到92%。所提出的使用MEG研究与局灶性致痫性和传播相关异常的方法可以提供另一种非侵入性定位手段。
