Shibata Rei, Ouchi Noriyuki, Ohashi Koji, Murohara Toyoaki
Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Molecular Cardiovascular Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Cardiol. 2017 Oct;70(4):329-334. doi: 10.1016/j.jjcc.2017.02.006. Epub 2017 Mar 18.
Obesity leads to the development of cardiovascular diseases. Adipose tissue produces various bioactive molecules, also known as adipokines, and imbalanced production of adipokines contributes to the pathogenesis of obesity-linked metabolic and cardiovascular complications. Some adipokines such as adiponectin exert salutary actions on cardiovascular and metabolic disorders. Recent research has been conducted to identify poorly-characterized adipokines involved in cardiovascular regulation. In this review, we focus on the protective role of novel adipokines that are of current interest in the field of cardiology.
肥胖会导致心血管疾病的发生。脂肪组织会产生各种生物活性分子,也被称为脂肪因子,而脂肪因子的产生失衡会导致与肥胖相关的代谢和心血管并发症的发病机制。一些脂肪因子,如脂联素,对心血管和代谢紊乱具有有益作用。最近已经开展了研究,以确定参与心血管调节但特征尚不明确的脂肪因子。在这篇综述中,我们聚焦于新型脂肪因子在心脏病学领域当前受到关注的保护作用。