[双膦酸盐相关性颌骨坏死的研究进展]
[Research progress on bisphosphonate-related osteonecrosis of the jaws].
作者信息
Jian Pan, Qizhang Wang, Jiyuan Liu
机构信息
State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):29-36. doi: 10.7518/hxkq.2017.01.004.
Abstract
Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is clinically characterized by exposed bones, formation of sequestrum, pain, and halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments for this disease are currently unavailable. Thus, prevention plays an important role in the management of BRONJ. This review summarizes research progress on pathogenesis, risk factors, clinical characteristics, treatment, and prevention of this condition.
摘要
双膦酸盐（BPs）作为强效的骨吸收抑制药物，已被广泛用于多种疾病的治疗。近年来，牙医及口腔颌面外科医生报告的双膦酸盐相关颌骨坏死（BRONJ）病例持续增加。该疾病的临床特征为骨暴露、死骨形成、疼痛和口臭。鉴于BRONJ的发病机制尚不清楚，目前尚无针对该疾病的有效治疗方法。因此，预防在BRONJ的管理中起着重要作用。本综述总结了该疾病在发病机制、危险因素、临床特征、治疗及预防方面的研究进展。
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