从川西獐牙菜中大规模制备一种特定的呫吨酮并评估其α-葡萄糖苷酶抑制活性。
Large-Scale Preparation of a Specific Xanthone from Swertia mussotii and Evaluation of Its α-Glucosidase Inhibitory Activity.
作者信息
Chen Tao, Li Hongmei, Chen Chen, Wei Lixin, Li Yulin
机构信息
Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, No.23, Xinning Road, Xining 810008, P.R. China.
Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, No.23, Xinning Road, Xining 810008, P.R. China.
出版信息
J Chromatogr Sci. 2017 Jul 1;55(6):638-644. doi: 10.1093/chromsci/bmx020.
Large-scale preparation and α-glucosidase inhibitory activity of a specific xanthone swertioside from Swertia mussotii were investigated in this study. Firstly, an efficient method was successfully established by liquid-liquid extraction, preparative high-performance liquid chromatography and sephadex LH-20 for large-scale preparation of swertioside. The recovery of swertioside reached 92.0%. Secondly, in vitro α-glucosidase inhibition experiment showed that swertioside had good inhibition close to acarbose. The study showed that swertioside had potential use as an anti-diabetic agent.
本研究对川西獐牙菜中一种特定的氧杂蒽酮类化合物獐牙菜苷的大规模制备及其α-葡萄糖苷酶抑制活性进行了研究。首先，通过液液萃取、制备型高效液相色谱和葡聚糖凝胶LH-20成功建立了一种高效的大规模制备獐牙菜苷的方法。獐牙菜苷的回收率达到92.0%。其次，体外α-葡萄糖苷酶抑制实验表明，獐牙菜苷具有良好的抑制作用，接近阿卡波糖。该研究表明，獐牙菜苷具有作为抗糖尿病药物的潜在用途。
Zotero 插件