Matsui Shogo, Kajikawa Masato, Maruhashi Tatsuya, Iwamoto Yumiko, Iwamoto Akimichi, Oda Nozomu, Kishimoto Shinji, Hidaka Takayuki, Kihara Yasuki, Chayama Kazuaki, Goto Chikara, Aibara Yoshiki, Nakashima Ayumu, Noma Kensuke, Taguchi Akira, Higashi Yukihito
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Int J Cardiol. 2017 Aug 15;241:30-34. doi: 10.1016/j.ijcard.2017.03.049. Epub 2017 Mar 16.
Periodontal disease is associated with endothelial dysfunction, leading to cardiovascular disease. The effect of detailed tooth brushing behavior, not only frequency but also duration of tooth brushing, on endothelial function is unclear. The purpose of this study was to evaluate the relationships of detailed methods of tooth brushing with vascular function.
We evaluated flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation, and frequency and duration of tooth brushing in 896 subjects. We divided the subjects into three groups according to the frequency and duration of tooth brushing: low frequency and short duration group (<twice/day and <2min/procedure), low frequency or short duration group (<twice/day or <2min/procedure), non-low frequency and non-short duration group (≥twice/day and ≥2min/procedure).
FMD in the low frequency and short duration group was significantly lower than FMD in the low frequency or short duration group and FMD in the non-low frequency and non-short duration group [3.1 (2.7)% vs. 4.2 (3.1)% and 4.7 (3.1)%, P=0.001 and <0.001, respectively]. Nitroglycerine-induced vasodilation was similar in the three groups. Using the non-low frequency and non-short duration group as the reference, the low frequency and short duration of tooth brushing group was significantly associated with an increased odds ratio of a low FMD tertile after adjustment for conventional risk factors (OR: 2.25, 95% CI: 1.39-3.59; P<0.001).
These findings suggest that low frequency and short duration of tooth brushing are associated with endothelial dysfunction.
URL for clinical trial: http://UMIN; registration number for clinical trial: UMIN000003409.
牙周疾病与内皮功能障碍相关，进而导致心血管疾病。详细的刷牙行为，不仅包括刷牙频率，还包括刷牙时长，对内皮功能的影响尚不清楚。本研究的目的是评估详细的刷牙方法与血管功能之间的关系。
我们评估了896名受试者的血流介导的血管舒张（FMD）、硝酸甘油诱导的血管舒张以及刷牙频率和时长。我们根据刷牙频率和时长将受试者分为三组：低频短时长组（<每天两次且<每次2分钟）、低频或短时长组（<每天两次或<每次2分钟）、非低频非短时长组（≥每天两次且≥每次2分钟）。
低频短时长组的FMD显著低于低频或短时长组以及非低频非短时长组的FMD [分别为3.1（2.7）% vs. 4.2（3.1）%和4.7（3.1）%，P = 0.001和<0.001]。三组中硝酸甘油诱导的血管舒张相似。以非低频非短时长组为参照，在调整传统危险因素后，低频短时长刷牙组与FMD处于较低三分位数的比值比增加显著相关（比值比：2.25，95%置信区间：1.39 - 3.59；P < 0.001）。
这些发现表明，低频短时长刷牙与内皮功能障碍相关。
