作为抗癌剂的查尔酮并入喹唑啉衍生物的合成。
Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents.
作者信息
Madhavi Sapavat, Sreenivasulu Reddymasu, Yazala Jyothsna Pragathi, Raju Rudraraju Ramesh
机构信息
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, Andhra Pradesh, India.
出版信息
Saudi Pharm J. 2017 Feb;25(2):275-279. doi: 10.1016/j.jsps.2016.06.005. Epub 2016 Jun 24.
A series of ten novel chalcone incorporated quinazoline derivatives (-) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375). Among them, four compounds, , , and showed more potent anticancer activity than the control drug, Combretastatin - A4.
设计并合成了一系列十种新型的含查尔酮喹唑啉衍生物（-）。对所有合成的化合物针对四种人类癌细胞系（A549、HT-29、MCF-7和A375）进行了抗癌活性评估。其中，四种化合物， 、 、 和 显示出比对照药物Combretastatin - A4更强的抗癌活性。
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