不对称Notch信号放大以确保干细胞特性
Asymmetric Notch Amplification to Secure Stem Cell Identity.
作者信息
Rossi Anthony M, Desplan Claude
机构信息
Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
出版信息
Dev Cell. 2017 Mar 27;40(6):513-514. doi: 10.1016/j.devcel.2017.03.010.
Abstract
Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.
摘要
干细胞能够自我更新并产生增殖潜力有限的祖细胞。刘等人（2017年）在《发育细胞》杂志上发表报告称，他们发现，在一些神经干细胞中，Notch信号活性通过与超级延伸复合物（SEC）形成的正反馈回路而不对称放大，从而迅速区分干细胞和祖细胞。
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