Monda Vincenzo, Villano Ines, Messina Antonietta, Valenzano Anna, Esposito Teresa, Moscatelli Fiorenzo, Viggiano Andrea, Cibelli Giuseppe, Chieffi Sergio, Monda Marcellino, Messina Giovanni
Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, Naples, Italy.
Department of Clinical and Experimental Medicine University of Foggia, Foggia, Italy.
Oxid Med Cell Longev. 2017;2017:3831972. doi: 10.1155/2017/3831972. Epub 2017 Mar 5.
The human gastrointestinal tract (GIT) is inhabited by a wide cluster of microorganisms that play protective, structural, and metabolic functions for the intestinal mucosa. Gut microbiota is involved in the barrier functions and in the maintenance of its homeostasis. It provides nutrients, participates in the signaling network, regulates the epithelial development, and affects the immune system. Considering the microbiota ability to respond to homeostatic and physiological changes, some researchers proposed that it can be seen as an endocrine organ. Evidence suggests that different factors can determine changes in the gut microbiota. These changes can be both quantitative and qualitative resulting in variations of the composition and metabolic activity of the gut microbiota which, in turn, can affect health and different disease processes. Recent studies suggest that exercise can enhance the number of beneficial microbial species, enrich the microflora diversity, and improve the development of commensal bacteria. All these effects are beneficial for the host, improving its health status. In this paper, we intend to shed some light over the recent knowledge of the role played by exercise as an environmental factor in determining changes in microbial composition and how these effects could provide benefits to health and disease prevention.
人类胃肠道(GIT)中栖息着大量微生物群,它们对肠黏膜发挥着保护、结构和代谢功能。肠道微生物群参与屏障功能及其体内平衡的维持。它提供营养、参与信号网络、调节上皮发育并影响免疫系统。考虑到微生物群对体内平衡和生理变化的反应能力,一些研究人员提出可将其视为一个内分泌器官。有证据表明,不同因素可决定肠道微生物群的变化。这些变化可以是数量上的,也可以是质量上的,从而导致肠道微生物群的组成和代谢活性发生变化,进而影响健康和不同的疾病进程。最近的研究表明,运动可以增加有益微生物种类的数量,丰富微生物群落多样性,并促进共生细菌的生长。所有这些效应都对宿主有益,可改善其健康状况。在本文中,我们旨在阐明运动作为一种环境因素在决定微生物组成变化中所起作用的最新知识,以及这些效应如何为健康和疾病预防带来益处。