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内镜下支架缝合固定术预防贲门失弛缓症治疗中长时间扩张时食管支架移位

Endoscopic stent suture fixation for prevention of esophageal stent migration during prolonged dilatation for achalasia treatment.

作者信息

Rieder E, Asari R, Paireder M, Lenglinger J, Schoppmann S F

出版信息

Dis Esophagus. 2017 Apr 1;30(4):1-6. doi: 10.1093/dote/dow002.

Abstract

The aim of this study is to compare endoscopic stent suture fixation with endoscopic clip attachment or the use of partially covered stents (PCS) regarding their capability to prevent stent migration during prolonged dilatation in achalasia. Large-diameter self-expanding metal stents (30 mm × 80 mm) were placed across the gastroesophageal junction in 11 patients with achalasia. Stent removal was scheduled after 4 to 7 days. To prevent stent dislocation, endoscopic clip attachment, endoscopic stent suture fixation, or PCS were used. The Eckardt score was evaluated before and 6 months after prolonged dilatation. After endoscopic stent suture fixation, no (0/4) sutured stent migrated. When endoscopic clips were used, 80% (4/5) clipped stents migrated (p = 0.02). Of two PCS (n = 2), one migrated and one became embedded leading to difficult stent removal. Technical adverse events were not seen in endoscopic stent suture fixation but were significantly correlated with the use of clips or PCS (r = 0.828, p = 0.02). Overall, 72% of patients were in remission regarding their achalasia symptoms 6 months after prolonged dilatation. Endoscopic suture fixation of esophageal stents but not clip attachment appears to be the best method of preventing early migration of esophageal stents placed at difficult locations such as at the naive gastroesophageal junction.

摘要

本研究的目的是比较内镜下支架缝合固定术与内镜下夹子固定术或使用部分覆盖支架(PCS)在预防贲门失弛缓症长期扩张过程中支架移位方面的能力。将大直径自膨式金属支架(30 mm×80 mm)放置在11例贲门失弛缓症患者的胃食管交界处。计划在4至7天后取出支架。为防止支架脱位,采用了内镜下夹子固定术、内镜下支架缝合固定术或PCS。在长期扩张前和扩张6个月后评估埃卡德特评分。内镜下支架缝合固定术后,无(0/4)缝合支架移位。使用内镜夹子时,80%(4/5)的夹闭支架发生移位(p = 0.02)。在两个PCS(n = 2)中,一个发生移位,一个嵌入导致支架取出困难。内镜下支架缝合固定术未出现技术不良事件,但与使用夹子或PCS显著相关(r = 0.828,p = 0.02)。总体而言,长期扩张6个月后,72%的患者贲门失弛缓症症状缓解。食管支架的内镜缝合固定而非夹子固定似乎是防止放置在困难位置(如原始胃食管交界处)的食管支架早期移位的最佳方法。

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